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Systematic reviews – that is, research reviews that are rigorous and follow scientific methods – are increasingly important for assisting stakeholders in implementing evidence-based decision making for children and adults with disabilities. Yet, systematic reviews vary greatly in quality and are therefore not a panacea. Distinguishing “good” reviews from “bad” reviews requires time and skills related to the appraisal of systematic reviews. The purpose of this chapter is to inform stakeholders (i.e., practitioners, administrators, policy makers) of evidence-based information sources that provide synopses (i.e., appraisals) of systematic reviews, to provide guidance in reading and interpreting the synopses of various sources, and to propose how to make sense of multiple synopses from different sources for the same systematic review. A secondary purpose of this chapter is to illustrate how stakeholders can conduct their own appraisals if synopses are not available.