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This scientific article aims to evaluate the efficacy of the drug Doxorubicin for treating hepatocellular carcinoma (HCC) in Egypt. The study analyzes data from patients referred to a multi-disciplinary consultation at the National Cancer Institute, Cairo University. The study includes 40 intermediate-stage HCC patients who underwent treatment with either Doxorubicin-Lipiodol or Doxorubicin-loaded drug-eluting beads-trans-arterial chemoembolization (DEB-TACE).

Patients referred to a multi-disciplinary consultation at the National Cancer Institute, Cairo University with a possible diagnosis of HCC in the intermediate stage were eligible for the study.

The study finds that the plasma peak concentration of Doxorubicin is significantly higher in patients treated with Lipiodol compared to those treated with DEB-TACE. The median plasma peak concentration of patients treated with Lipiodol was significantly higher 424 (202.5–731) than the peak level of patients treated with beads 84.95 (26.6–156.5) with p-value = 0.036. However, there is no significant difference in other pharmacokinetic parameters between the two treatment groups. The research article also investigates the genetic polymorphisms in HCC patients treated with Doxorubicin-Lipiodol and Doxorubicin-loaded DEB-TACE. It identifies a significant association between the ABCB1 gene (C3435T) and the concentration of Doxorubicin in plasma. Patients with the CCand computed tomography (CT) genotypes of ABCB1 have higher concentrations of Doxorubicin compared to those with the TT genotype. Furthermore, the study examines the progression-free survival rates and tumour response in the two treatment groups. It demonstrates that DEB-TACE patients have a higher progression-free survival rate compared to cTACE patients. DEB-TACE also leads to better tumour regression.

The current study helps to increase the understanding of the genetic factors that may contribute to HCC susceptibility in the Egyptian population. However, it is essential to consider that genetic polymorphism is just one aspect of HCC risk, and other factors such as environment, lifestyle and viral infections also play crucial roles. Further research is needed to elucidate the complex interactions between genetic and environmental factors in HCC development among Egyptians.

The objective of this research is to evaluate the influence of mineral additions on the mechanical performances of polymer concrete. This study aims to propose a novel approach formulation of polymer concrete based on reduction in the quantity of the binder and disposal of large quantities of industrial by-products and household waste such as the marble, the brick and silica fume whose valuation in polymer concrete could be an interesting ecological and economical alternative. The incorporation of a rate of 10% brick powder affects the distribution of pores inside polymer concrete, that is, the pore diameters become thinner and decrease and the porosity becomes evenly distributed. The recycled mineral brick powder addition in polymer concrete mix improved the mechanical properties.

This polymer concrete was prepared by using polyester resin and two different types of sand, following a new formulation based on an empirical method. Furthermore, the optimal binder percentage was of 20% resin and a mixture of 52% dune sand and 48% quarry sand according to the Abrams method. To achieve our objective, five rates (from 2% to 10%) of brick powder, marble powder and silica fume were examined. Afterwards, its mechanical characteristics were evaluated via a three-point flexural with compressive resistance. The findings indicated that the addition of brick, marble and silica fume to polymer concrete increases the flexural strength with 21.84%, 12.76% and 9.07%, respectively.

Concerning the compressive strength, the best resistance is that of polymer concretes based on brick powder, and this economic formulation of polymer concrete serves the optimal cost/resistance ratio criteria. It allows an improvement in the mechanical resistance of concrete are obtained by adding brick powder that exceed that of the reference concrete.

In the past few decades, there has been several contribution concerning the subject of the reduction of the binder quantity in polymer concretes and adding the industrial and household wastes. However, previous studies revolving around the same area disregarded the effect of the brick powder, which appears scientifically of great importance for enriching the literature.